Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

Evidence for a Gene-Gene Interaction

In four large pedigrees with heterozygous familial hypercholesterolemia (FH) genetically linked to the low density lipoprotein receptor locus, we have observed a strong interaction between the presence of FH and a single apolipoprotein (apo) E2 allele, resulting in a markedly increased prevalence of type III dyslipoproteinemia (DLPIII). DLPIII was denned by chemical criteria. None of the patien...

A Gene-Environment Interaction

Background—Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associat...

Commentary: thoughts on assessing evidence for gene by environment interaction.

The commentary in this issue by Boffetta et al. addresses a challenging problem: given that a genetic factor, G, and an environmental factor, E, might both influence risk of cancer, how can we systematically assess the accumulated published evidence for the existence of interaction between them? Most complex diseases, not just cancer, probably arise through a web of factors that are both geneti...

Smoking and reverse cholesterol transport: evidence for gene-environment interaction.